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Special care may be needed.<br /> <h3><u>What if I miss a dose?</u></h3><br /> If you miss a dose, take it with the next meal. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.<br /> <u>What drug(s) may interact with pioglitazone?<br /> </u>• atorvastatin<br /> • birth control pills or other hormonal methods of birth control<br /> • bosentan<br /> • itraconazole<br /> • ketoconazole<br /> • midazolam<br /> • nifedipine <br /> • other medicines for diabetes, including insulin<br /> • topiramate<br /> <br /> <p><h4> Many medications may cause changes (increase or decrease) in blood sugar, these include:</h4></p> • alcohol containing beverages<br /> • angiotensin converting enzyme inhibitors (ACE inhibitors), often used for high blood pressure or heart problems (examples: captopril, enalapril, lisinopril)<br /> • antiretroviral protease inhibitors (examples: indinavir, ritonavir, saquinavir)<br /> • aspirin and aspirin-like drugs<br /> • baclofen<br /> • beta-blockers, often used for high blood pressure or heart problems (examples include atenolol, metoprolol, propranolol)<br /> • certain medicines used for mental depression, emotional, or psychotic disturbances<br /> • chromium<br /> • cisapride<br /> • clonidine<br /> • cyclosporine<br /> • diazoxide<br /> • disopyramide<br /> • epinephrine<br /> • female hormones, such as estrogens or progestins, birth control pills<br /> • fibric acid derivatives, used to treat high cholesterol (examples: fenofibrate and gemfibrozil)<br /> • glucagon<br /> • growth hormone (somatropin)<br /> • guanethidine<br /> • isoniazid<br /> • lithium<br /> • metoclopramide<br /> • male hormones or anabolic steroids<br /> • medications to suppress appetite or for weight loss<br /> • medicines for allergies, asthma, cold, or cough<br /> • niacin<br /> • nicotine (including nicotine found in patches and gum)<br /> • octreotide<br /> • pentamidine<br /> • phenytoin<br /> • quinolone antibiotics (examples: ciprofloxacin, levofloxacin, ofloxacin)<br /> • some herbal dietary supplements<br /> • steroid medicines such as prednisone or cortisone<br /> • sulfonamides, medicines for infection (examples: Azulfidine®, Bactrim®, Gantrisin® Septra®) <br /> • tacrolimus<br /> • tegaserod<br /> • thyroid hormones<br /> • water pills (diuretics)<br /> <br /> Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.<br /> <h3><u>What side effects may I notice from taking pioglitazone?</u></h3><br /> <p><h4> Side effects that you should report to your prescriber or health care professional as soon as possible:</h4></p> • anxiety or nervousness, confusion, difficulty concentrating<br /> • blurred vision<br /> • breathing problems such as rapid, deep breathing or difficulty breathing with activity<br /> • cold sweats, increased sweating<br /> • cool, pale skin<br /> • dark yellow or brown urine, or yellowing of the eyes or skin<br /> • diarrhea<br /> • drowsiness<br /> • muscle pain<br /> • nausea, vomiting<br /> • skin rash or hives<br /> • slow heartbeat<br /> • tremors or shakiness<br /> • unusual tiredness or weakness<br /> • swelling of the hands, legs, and/or feet<br /> <br /> <p><h4> Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):</h4></p> • headache<br /> • weight gain<br /> <h3><u>What should I watch for while taking pioglitazone?</u></h3><br /> Visit your prescriber or health care professional for regular checks on your progress. Learn how to monitor blood or urine sugar and urine ketones regularly. Check with your prescriber or health care professional if your blood sugar is high, you may need a change of dose of pioglitazone. Do not skip meals. If you are exercising much more than usual you may need extra snacks to avoid side effects caused by low blood sugar. If you have mild symptoms of low blood sugar, eat or drink something containing sugar at once and contact your prescriber or health care professional. It is wise to check your blood sugar to confirm that it is low. It is important to recognize your own symptoms of low blood sugar so that you can treat them quickly. Make sure family members know that you can choke if you eat or drink when you have serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.<br /> <br /> Your health care professional will have to check blood tests regularly to assess the effect of this medication on your liver. 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